SHC4
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SHC adaptor protein 4 | MIM:617372 | Ensembl:ENSG00000185634 | HGNC:HGNC:16743 | PA142670917 | 15q21.1 |
GO terms in SHC4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0030971 | receptor tyrosine kinase binding |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0048863 | stem cell differentiation |
| CC | IEA | GO:0005622 | intracellular |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0045211 | postsynaptic membrane |
Gene expression in normal tissue: SHC4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SHC4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_BDNF | BDNF |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4223 | Ras Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SHC4
CLASSFICATION
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