CENPP


Summary: CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:611505
PHARMGKB IDPA145149143
Map Location9q22.31

GO terms in CENPP


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000775 chromosome, centromeric region
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005730 nucleolus
CC TAS GO:0005829 cytosol
BP TAS GO:0034080 CENP-A containing nucleosome assembly
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Gene expression in normal tissue: CENPP

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in CENPP


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Database
Pathway ID
Pathway Des.
reactome R-HSA-141424 Amplification of signal from the kinetochores
reactome R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-195258 RHO GTPase Effectors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CENPP

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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