KPNA7
Summary: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| karyopherin subunit alpha 7 | MIM:614107 | Ensembl:ENSG00000185467 | HGNC:HGNC:21839 | PA164722048 | 7q22.1 |
Gene Categories:
TRANSPORTERGO terms in KPNA7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0061608 | nuclear import signal receptor activity |
| MF | IEA | GO:0061608 | nuclear import signal receptor activity |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0019054 | modulation by virus of host process |
Gene expression in normal tissue: KPNA7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KPNA7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KPNA7
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