ARL3
Summary: ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADP ribosylation factor like GTPase 3 | MIM:604695 | Ensembl:ENSG00000138175 | HGNC:HGNC:694 | PA24987 | 10q24.32 |
GO terms in ARL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005525 | GTP binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0019003 | GDP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IMP | GO:0000281 | mitotic cytokinesis |
| BP | ISS | GO:0001822 | kidney development |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006892 | post-Golgi vesicle-mediated transport |
| BP | IEA | GO:0007224 | smoothened signaling pathway |
| BP | IDA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0042073 | intraciliary transport |
| BP | ISS | GO:0042461 | photoreceptor cell development |
| BP | IBA | GO:0060271 | cilium assembly |
| BP | IMP | GO:0060271 | cilium assembly |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0005929 | cilium |
| CC | IDA | GO:0005929 | cilium |
| CC | TAS | GO:0005929 | cilium |
| CC | IBA | GO:0015630 | microtubule cytoskeleton |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0032391 | photoreceptor connecting cilium |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ARL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620920 | Cargo trafficking to the periciliary membrane |
| reactome | R-HSA-5624138 | Trafficking of myristoylated proteins to the cilium |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARL3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.