LRP2
Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LDL receptor related protein 2 | MIM:600073 | Ensembl:ENSG00000081479 | HGNC:HGNC:6694 | PA30452 | 2q31.1 |
GO terms in LRP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | ISS | GO:0001843 | neural tube closure |
| BP | ISS | GO:0003139 | secondary heart field specification |
| BP | ISS | GO:0003148 | outflow tract septum morphogenesis |
| BP | ISS | GO:0003223 | ventricular compact myocardium morphogenesis |
| BP | IEA | GO:0003281 | ventricular septum development |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006897 | endocytosis |
| BP | IDA | GO:0006898 | receptor-mediated endocytosis |
| BP | ISS | GO:0006898 | receptor-mediated endocytosis |
| BP | ISS | GO:0007605 | sensory perception of sound |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | ISS | GO:0008584 | male gonad development |
| BP | IDA | GO:0030001 | metal ion transport |
| BP | ISS | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IEA | GO:0030900 | forebrain development |
| BP | IEA | GO:0035904 | aorta development |
| BP | TAS | GO:0042359 | vitamin D metabolic process |
| BP | IEA | GO:0042953 | lipoprotein transport |
| BP | ISS | GO:0050769 | positive regulation of neurogenesis |
| BP | ISS | GO:0060068 | vagina development |
| BP | ISS | GO:0060982 | coronary artery morphogenesis |
| BP | TAS | GO:0061024 | membrane organization |
| BP | ISS | GO:0061156 | pulmonary artery morphogenesis |
| BP | ISS | GO:0070447 | positive regulation of oligodendrocyte progenitor proliferation |
| BP | ISS | GO:0140058 | neuron projection arborization |
| BP | ISS | GO:1904447 | folate import across plasma membrane |
| BP | ISS | GO:1905167 | positive regulation of lysosomal protein catabolic process |
| CC | TAS | GO:0005764 | lysosome |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005905 | clathrin-coated pit |
| CC | ISS | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0030139 | endocytic vesicle |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | ISS | GO:0031526 | brush border membrane |
| CC | IEA | GO:0031904 | endosome lumen |
| CC | IDA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0005041 | low-density lipoprotein particle receptor activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008144 | drug binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | ISS | GO:0035258 | steroid hormone receptor binding |
| MF | TAS | GO:0042954 | lipoprotein transporter activity |
| MF | IPI | GO:0051087 | chaperone binding |
| MF | ISS | GO:0051087 | chaperone binding |
Gene expression in normal tissue: LRP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-196791 | Vitamin D (calciferol) metabolism |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD446 | LY 2183240 | 9 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD512 | nutlin 3 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRP2
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