LRP2


Summary: The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LDL receptor related protein 2MIM:600073Ensembl:ENSG00000081479HGNC:HGNC:6694PA304522q31.1

GO terms in LRP2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0001523retinoid metabolic process
BPISSGO:0001843neural tube closure
BPISSGO:0003139secondary heart field specification
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003223ventricular compact myocardium morphogenesis
BPIEAGO:0003281ventricular septum development
BPTASGO:0006629lipid metabolic process
BPTASGO:0006897endocytosis
BPIDAGO:0006898receptor-mediated endocytosis
BPISSGO:0006898receptor-mediated endocytosis
BPISSGO:0007605sensory perception of sound
BPIEAGO:0008283cell proliferation
BPISSGO:0008584male gonad development
BPIDAGO:0030001metal ion transport
BPISSGO:0030514negative regulation of BMP signaling pathway
BPIEAGO:0030900forebrain development
BPIEAGO:0035904aorta development
BPTASGO:0042359vitamin D metabolic process
BPIEAGO:0042953lipoprotein transport
BPISSGO:0050769positive regulation of neurogenesis
BPISSGO:0060068vagina development
BPISSGO:0060982coronary artery morphogenesis
BPTASGO:0061024membrane organization
BPISSGO:0061156pulmonary artery morphogenesis
BPISSGO:0070447positive regulation of oligodendrocyte progenitor proliferation
BPISSGO:0140058neuron projection arborization
BPISSGO:1904447folate import across plasma membrane
BPISSGO:1905167positive regulation of lysosomal protein catabolic process
CCTASGO:0005764lysosome
CCHDAGO:0005765lysosomal membrane
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCIEAGO:0005905clathrin-coated pit
CCISSGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0016324apical plasma membrane
CCISSGO:0016324apical plasma membrane
CCIEAGO:0030139endocytic vesicle
CCISSGO:0030424axon
CCISSGO:0030425dendrite
CCTASGO:0030665clathrin-coated vesicle membrane
CCISSGO:0031526brush border membrane
CCIEAGO:0031904endosome lumen
CCIDAGO:0043235receptor complex
CCHDAGO:0070062extracellular exosome
MFTASGO:0005041low-density lipoprotein particle receptor activity
MFIDAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFISSGO:0008144drug binding
MFIEAGO:0017124SH3 domain binding
MFISSGO:0035258steroid hormone receptor binding
MFTASGO:0042954lipoprotein transporter activity
MFIPIGO:0051087chaperone binding
MFISSGO:0051087chaperone binding

Gene expression in normal tissue: LRP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LRP2


DatabasePathway IDPathway Des.
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP2806Human Complement System
wikipathwaysWP4249Hedgehog Signaling Pathway
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04979Cholesterol metabolism - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-196791Vitamin D (calciferol) metabolism
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6806667Metabolism of fat-soluble vitamins
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-975634Retinoid metabolism and transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD451Serdemetan2
iGMDRD64Parbendazole2
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib3
iGMDRD441TW 372
iGMDRD52Rotenone3
iGMDRD187BRD98761
iGMDRD782DC-45-A23
iGMDRD255SB2250025
iGMDRD138PX 122
iGMDRD474Avrainvillamide2
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B7
iGMDRD748PHA-6657521
iGMDRD446LY 21832409
iGMDRD546BMS-7548072
iGMDRD772BRD47703
iGMDRD579PF7503
iGMDRD420Leucascandrolide A3
iGMDRD126Tipifarnib3
iGMDRD246NPC263
iGMDRD552AZD-17751
iGMDRD286Nsc 6328394
iGMDRD871BRD63683
iGMDRD414MST-3125
iGMDRD68Paclitaxel1
iGMDRD705Nakiterpiosin6
iGMDRD289Parthenolide2
iGMDRD103SN-382
iGMDRD202Curcumin3
iGMDRD121GMX17782
iGMDRD945ML2142
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide3
iGMDRD57Chloropentafluorobenzene2
iGMDRD351GW843682X2
iGMDRD341Triacsin c4
iGMDRD79Gemcitabine3
iGMDRD116CD4373
iGMDRD424Tamatinib3
iGMDRD512nutlin 32

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRP2

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