Summary: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

LDL receptor related protein 5MIM:603506Ensembl:ENSG00000162337HGNC:HGNC:6697PA3045511q13.2

GO terms in LRP5

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005783endoplasmic reticulum
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCTASGO:1990851Wnt-Frizzled-LRP5/6 complex
CCNASGO:1990909Wnt signalosome
BPIBAGO:0001702gastrulation with mouth forming second
BPIEAGO:0001702gastrulation with mouth forming second
BPIMPGO:0002053positive regulation of mesenchymal cell proliferation
BPIBAGO:0002076osteoblast development
BPIMPGO:0006007glucose catabolic process
BPIEAGO:0008203cholesterol metabolic process
BPIMPGO:0008217regulation of blood pressure
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009314response to radiation
BPIBAGO:0009952anterior/posterior pattern specification
BPIEAGO:0009952anterior/posterior pattern specification
BPIDAGO:0016055Wnt signaling pathway
BPIGIGO:0016055Wnt signaling pathway
BPIBAGO:0030278regulation of ossification
BPIEAGO:0033690positive regulation of osteoblast proliferation
BPIEAGO:0035019somatic stem cell population maintenance
BPIEAGO:0035426extracellular matrix-cell signaling
BPIEAGO:0042074cell migration involved in gastrulation
BPIBAGO:0042632cholesterol homeostasis
BPIMPGO:0042632cholesterol homeostasis
BPIEAGO:0042733embryonic digit morphogenesis
BPIEAGO:0042981regulation of apoptotic process
BPIEAGO:0043434response to peptide hormone
BPIBAGO:0044332Wnt signaling pathway involved in dorsal/ventral axis specification
BPIDAGO:0044332Wnt signaling pathway involved in dorsal/ventral axis specification
BPIMPGO:0045600positive regulation of fat cell differentiation
BPIMPGO:0045668negative regulation of osteoblast differentiation
BPIDAGO:0045840positive regulation of mitotic nuclear division
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0046849bone remodeling
BPIEAGO:0046849bone remodeling
BPIEAGO:0046850regulation of bone remodeling
BPIBAGO:0048539bone marrow development
BPIMPGO:0048539bone marrow development
BPIEAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0060033anatomical structure regression
BPIMPGO:0060042retina morphogenesis in camera-type eye
BPIBAGO:0060070canonical Wnt signaling pathway
BPIDAGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPIBAGO:0060349bone morphogenesis
BPIMPGO:0060349bone morphogenesis
BPIBAGO:0060444branching involved in mammary gland duct morphogenesis
BPIEAGO:0060444branching involved in mammary gland duct morphogenesis
BPIBAGO:0060612adipose tissue development
BPIMPGO:0060612adipose tissue development
BPIEAGO:0060764cell-cell signaling involved in mammary gland development
BPIGIGO:0060828regulation of canonical Wnt signaling pathway
BPIMPGO:0060828regulation of canonical Wnt signaling pathway
BPIBAGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus
BPIBAGO:0061304retinal blood vessel morphogenesis
BPIMPGO:0061304retinal blood vessel morphogenesis
BPIMPGO:0071901negative regulation of protein serine/threonine kinase activity
BPIEAGO:1902262apoptotic process involved in blood vessel morphogenesis
MFIPIGO:0005515protein binding
MFIBAGO:0015026coreceptor activity
MFIBAGO:0017147Wnt-protein binding
MFIPIGO:0017147Wnt-protein binding
MFISSGO:0017147Wnt-protein binding
MFTASGO:0017147Wnt-protein binding
MFIMPGO:0019534toxin transmembrane transporter activity
MFIBAGO:0042813Wnt-activated receptor activity
MFISSGO:0042813Wnt-activated receptor activity
MFIPIGO:0071936coreceptor activity involved in Wnt signaling pathway
MFNASGO:1904928coreceptor activity involved in canonical Wnt signaling pathway

Gene expression in normal tissue: LRP5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LRP5

DatabasePathway IDPathway Des.
pidncadherinpathwayN-cadherin signaling events
pidwnt_signaling_pathwayWnt signaling network
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP428Wnt Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonists
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641263Regulation of FZD by ubiquitination
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
reactomeR-HSA-5340588RNF mutants show enhanced WNT signaling and proliferation
reactomeR-HSA-5663202Diseases of signal transduction

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRP5