LRPAP1
Summary: This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:104225 Ensembl IDEnsembl:ENSG00000163956 HGNC IDHGNC:HGNC:6701 PHARMGKB IDPA30458 Map Location4p16.3 | |||||
GO terms in LRPAP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0001540 | amyloid-beta binding |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008201 | heparin binding |
| MF | IEA | GO:0035473 | lipase binding |
| MF | IDA | GO:0048019 | receptor antagonist activity |
Gene expression in normal tissue: LRPAP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRPAP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | integrinpathway | integrin signaling pathway |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| pid | lis1pathway | Lissencephaly gene (LIS1) in neuronal migration and development |
| pid | reelinpathway | Reelin signaling pathway |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRPAP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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