LTA
Summary: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:153440 Ensembl IDEnsembl:ENSG00000226979 HGNC IDHGNC:HGNC:6709 PHARMGKB IDPA30474 Map Location6p21.33 | |||||
GO terms in LTA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0002876 | positive regulation of chronic inflammatory response to antigenic stimulus |
Gene expression in normal tissue: LTA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LTA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LTA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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