Summary: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].

lymphotoxin alphaMIM:153440Ensembl:ENSG00000226979HGNC:HGNC:6709PA304746p21.33

GO terms in LTA

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005102signaling receptor binding
MFIEAGO:0005125cytokine activity
MFIEAGO:0005164tumor necrosis factor receptor binding
MFIPIGO:0005515protein binding
BPIEAGO:0001666response to hypoxia
BPIEAGO:0002876positive regulation of chronic inflammatory response to antigenic stimulus
BPIEAGO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulin
BPTASGO:0006915apoptotic process
BPIEAGO:0006959humoral immune response
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007584response to nutrient
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0032729positive regulation of interferon-gamma production
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPIEAGO:0042493response to drug
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0044130negative regulation of growth of symbiont in host
BPIEAGO:0048147negative regulation of fibroblast proliferation
BPIEAGO:0048535lymph node development
BPIEAGO:0050830defense response to Gram-positive bacterium
BPIEAGO:0060252positive regulation of glial cell proliferation
CCIEAGO:0005615extracellular space
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: LTA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LTA

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
biocartatnfr2pathwaytnfr2 signaling pathway
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil4_2pathwayIL4-mediated signaling events
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
wikipathwaysWP3639Apoptotic Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LTA