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LTA

Summary: The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
lymphotoxin alpha	MIM:153440	Ensembl:ENSG00000226979	HGNC:HGNC:6709	PA30474	6p21.33

Gene Categories:

DRUG RESISTANCE DRUGGABLE GENOME

GO terms in LTA

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0005102	signaling receptor binding
MF	IEA	GO:0005125	cytokine activity
MF	IEA	GO:0005164	tumor necrosis factor receptor binding
MF	IPI	GO:0005515	protein binding
BP	IEA	GO:0001666	response to hypoxia
BP	IEA	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
BP	IEA	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
BP	TAS	GO:0006915	apoptotic process
BP	IEA	GO:0006959	humoral immune response
BP	TAS	GO:0007165	signal transduction
BP	TAS	GO:0007267	cell-cell signaling
BP	IEA	GO:0007584	response to nutrient
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IEA	GO:0032496	response to lipopolysaccharide
BP	IEA	GO:0032729	positive regulation of interferon-gamma production
BP	TAS	GO:0033209	tumor necrosis factor-mediated signaling pathway
BP	IEA	GO:0042493	response to drug
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	IEA	GO:0044130	negative regulation of growth of symbiont in host
BP	IEA	GO:0048147	negative regulation of fibroblast proliferation
BP	IEA	GO:0048535	lymph node development
BP	IEA	GO:0050830	defense response to Gram-positive bacterium
BP	IEA	GO:0060252	positive regulation of glial cell proliferation
CC	IEA	GO:0005615	extracellular space
CC	TAS	GO:0005886	plasma membrane

Gene expression in normal tissue: LTA

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LTA

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-5668541	TNFR2 non-canonical NF-kB pathway
reactome	R-HSA-5668541	TNFR2 non-canonical NF-kB pathway
reactome	R-HSA-5669034	TNFs bind their physiological receptors
reactome	R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
reactome	R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
biocarta	tnfr2pathway	tnfr2 signaling pathway
pid	il2_stat5pathway	IL2 signaling events mediated by STAT5
pid	il4_2pathway	IL4-mediated signaling events
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04064	NF-kappa B signaling pathway - Homo sapiens (human)
kegg	hsa04668	TNF signaling pathway - Homo sapiens (human)
kegg	hsa04940	Type I diabetes mellitus - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05168	Herpes simplex infection - Homo sapiens (human)
wikipathways	WP254	Apoptosis
wikipathways	WP3639	Apoptotic Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LTA

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DATATYPES

CLASSFICATION

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