LYZ
Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namelysozyme OMIM IDMIM:153450 Ensembl IDEnsembl:ENSG00000090382 HGNC IDHGNC:HGNC:6740 PHARMGKB IDPA30503 Map Location12q15 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in LYZ
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003796 | lysozyme activity |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005615 | extracellular space |
Gene expression in normal tissue: LYZ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LYZ
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
| reactome | R-HSA-977225 | Amyloid fiber formation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LYZ
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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