MIR223


Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
microRNA 223MIM:300694Ensembl:ENSG00000284567HGNC:HGNC:31603PA164722611Xq12

GO terms in MIR223


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0034260negative regulation of GTPase activity
BPIDAGO:0035195gene silencing by miRNA
BPIEAGO:0035195gene silencing by miRNA
BPIDAGO:0046326positive regulation of glucose import
BPIDAGO:1901342regulation of vasculature development
BPIDAGO:1903078positive regulation of protein localization to plasma membrane
BPIDAGO:1904706negative regulation of vascular smooth muscle cell proliferation
BPIDAGO:1904753negative regulation of vascular associated smooth muscle cell migration
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIEAGO:0035068micro-ribonucleoprotein complex
CCISSGO:0048471perinuclear region of cytoplasm
MFIDAGO:1903231mRNA binding involved in posttranscriptional gene silencing

Gene expression in normal tissue: MIR223

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MIR223


DatabasePathway IDPathway Des.
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MIR223

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