TM4SF1

Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametransmembrane 4 L six family member 1
OMIM IDMIM:191155
Ensembl IDEnsembl:ENSG00000169908
HGNC IDHGNC:HGNC:11853
PHARMGKB IDPA36554
Map Location3q25.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TM4SF1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ND GO:0003674 molecular_function
MF IPI GO:0005515 protein binding
BP ND GO:0008150 biological_process
CC IDA GO:0005887 integral component of plasma membrane
CC IBA GO:0016021 integral component of membrane
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Gene expression in normal tissue: TM4SF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in TM4SF1


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TM4SF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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