Summary: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].

epithelial cell adhesion moleculeMIM:185535Ensembl:ENSG00000119888HGNC:HGNC:11529PA354932p21

GO terms in EPCAM

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIDAGO:0044877protein-containing complex binding
MFIBAGO:0098641cadherin binding involved in cell-cell adhesion
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005923bicellular tight junction
CCIDAGO:0005923bicellular tight junction
CCIEAGO:0009986cell surface
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0016324apical plasma membrane
CCIDAGO:0016328lateral plasma membrane
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001657ureteric bud development
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0023019signal transduction involved in regulation of gene expression
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0048863stem cell differentiation
BPTASGO:0050900leukocyte migration
BPIEAGO:0098609cell-cell adhesion
BPIDAGO:2000048negative regulation of cell-cell adhesion mediated by cadherin
BPIMPGO:2000648positive regulation of stem cell proliferation

Gene expression in normal tissue: EPCAM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPCAM

DatabasePathway IDPathway Des.
reactomeR-HSA-202733Cell surface interactions at the vascular wall

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPCAM