M6PR
Summary: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mannose-6-phosphate receptor, cation dependent | MIM:154540 | Ensembl:ENSG00000003056 | HGNC:HGNC:6752 | PA30513 | 12p13.31 |
GO terms in M6PR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005537 | mannose binding |
| MF | IEA | GO:0005537 | mannose binding |
| MF | IEA | GO:0015578 | mannose transmembrane transporter activity |
| MF | IBA | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:1905394 | retromer complex binding |
| MF | IMP | GO:1905394 | retromer complex binding |
| CC | IEA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005768 | endosome |
| CC | IBA | GO:0005770 | late endosome |
| CC | IEA | GO:0005770 | late endosome |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0030133 | transport vesicle |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | IBA | GO:0030904 | retromer complex |
| CC | IDA | GO:0030904 | retromer complex |
| CC | IPI | GO:0030904 | retromer complex |
| CC | TAS | GO:0032588 | trans-Golgi network membrane |
| CC | IBA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IBA | GO:0006622 | protein targeting to lysosome |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0008333 | endosome to lysosome transport |
| BP | IEA | GO:0015761 | mannose transmembrane transport |
| BP | IBA | GO:0033299 | secretion of lysosomal enzymes |
| BP | IEA | GO:0033299 | secretion of lysosomal enzymes |
| BP | TAS | GO:0061024 | membrane organization |
Gene expression in normal tissue: M6PR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in M6PR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432720 | Lysosome Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in M6PR
CLASSFICATION
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