Summary: This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011].

mannose-6-phosphate receptor, cation dependentMIM:154540Ensembl:ENSG00000003056HGNC:HGNC:6752PA3051312p13.31

GO terms in M6PR

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0005537mannose binding
MFIEAGO:0005537mannose binding
MFIEAGO:0015578mannose transmembrane transporter activity
MFIBAGO:0019904protein domain specific binding
MFIBAGO:1905394retromer complex binding
MFIMPGO:1905394retromer complex binding
CCIEAGO:0005765lysosomal membrane
CCIBAGO:0005770late endosome
CCIEAGO:0005770late endosome
CCIBAGO:0005802trans-Golgi network
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCTASGO:0030133transport vesicle
CCTASGO:0030665clathrin-coated vesicle membrane
CCIBAGO:0030904retromer complex
CCIDAGO:0030904retromer complex
CCIPIGO:0030904retromer complex
CCTASGO:0032588trans-Golgi network membrane
CCIBAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0048471perinuclear region of cytoplasm
BPIBAGO:0006622protein targeting to lysosome
BPTASGO:0006898receptor-mediated endocytosis
BPIEAGO:0007165signal transduction
BPTASGO:0008333endosome to lysosome transport
BPIEAGO:0015761mannose transmembrane transport
BPIBAGO:0033299secretion of lysosomal enzymes
BPIEAGO:0033299secretion of lysosomal enzymes
BPTASGO:0061024membrane organization

Gene expression in normal tissue: M6PR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in M6PR

DatabasePathway IDPathway Des.
kegghsa04142Lysosome - Homo sapiens (human)
kegghsa04145Phagosome - Homo sapiens (human)
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432720Lysosome Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6811440Retrograde transport at the Trans-Golgi-Network
reactomeR-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER traffic
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in M6PR