SMAD6


Summary: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602931
PHARMGKB IDPA30529
Map Location15q22.31

GO terms in SMAD6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0003682 chromatin binding
MF IPI GO:0005515 protein binding
MF IDA GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
MF IMP GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
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Gene expression in normal tissue: SMAD6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

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Pathways in SMAD6


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Database
Pathway ID
Pathway Des.
biocarta alkpathway alk in cardiac myocytes
biocarta ctcfpathway ctcf: first multivalent nuclear factor
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-201451 Signaling by BMP
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-73857 RNA Polymerase II Transcription
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD39 Pyrimethamine 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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