SMAD6
Summary: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602931 Ensembl IDEnsembl:ENSG00000137834 HGNC IDHGNC:HGNC:6772 PHARMGKB IDPA30529 Map Location15q22.31 |
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXGO terms in SMAD6
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0003682 | chromatin binding |
MF | IPI | GO:0005515 | protein binding |
MF | IDA | GO:0030617 | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity |
MF | IMP | GO:0030617 | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity |
Gene expression in normal tissue: SMAD6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMAD6
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Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | alkpathway | alk in cardiac myocytes |
biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-201451 | Signaling by BMP |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD39 | Pyrimethamine | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SMAD6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |