SMAD9
Summary: The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603295 Ensembl IDEnsembl:ENSG00000120693 HGNC IDHGNC:HGNC:6774 PHARMGKB IDPA30531 Map Location13q13.3 | |||||
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXGO terms in SMAD9
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
Gene expression in normal tissue: SMAD9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SMAD9
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3876 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| humancyc | PWY66-11 | BMP Signalling Pathway |
| pid | alk1pathway | ALK1 signaling events |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SMAD9
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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