SMAD9


Summary: The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SMAD family member 9MIM:603295Ensembl:ENSG00000120693HGNC:HGNC:6774PA3053113q13.3

GO terms in SMAD9


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFTASGO:0030618transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
MFIEAGO:0046872metal ion binding
CCTASGO:0005622intracellular
CCISSGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005667transcription factor complex
CCISSGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCNASGO:0071141SMAD protein complex
BPIEAGO:0001657ureteric bud development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0007179transforming growth factor beta receptor signaling pathway
BPISSGO:0030509BMP signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIEAGO:0030901midbrain development
BPIEAGO:0030902hindbrain development
BPIEAGO:0051216cartilage development
BPIEAGO:0060348bone development
BPISSGO:0060395SMAD protein signal transduction
BPNASGO:0060395SMAD protein signal transduction
BPIEAGO:0071407cellular response to organic cyclic compound
BPNASGO:0071773cellular response to BMP stimulus
BPTASGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Gene expression in normal tissue: SMAD9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SMAD9


DatabasePathway IDPathway Des.
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP3876BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP560TGF-beta Receptor Signaling
humancycPWY66-11BMP Signalling Pathway
pidalk1pathwayALK1 signaling events
pidalk2pathwayALK2 signaling events
pidbmppathwayBMP receptor signaling
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SMAD9

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