MAFG
Summary: Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602020 Ensembl IDEnsembl:ENSG00000197063 HGNC IDHGNC:HGNC:6781 PHARMGKB IDPA30539 Map Location17q25.3 | |||||
GO terms in MAFG
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0030534 | adult behavior |
| BP | IEA | GO:0030641 | regulation of cellular pH |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
Gene expression in normal tissue: MAFG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAFG
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAFG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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