MBD1


Summary: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
methyl-CpG binding domain protein 1MIM:156535Ensembl:ENSG00000141644HGNC:HGNC:6916PA3065918q21.1

Gene Categories:

DRUG RESISTANCE

GO terms in MBD1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIEAGO:0005694chromosome
CCISSGO:0016363nuclear matrix
CCISSGO:0016607nuclear speck
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0006346methylation-dependent chromatin silencing
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPNASGO:0045892negative regulation of transcription, DNA-templated
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0008327methyl-CpG binding
MFIDAGO:0008327methyl-CpG binding
MFNASGO:0008327methyl-CpG binding
MFIDAGO:0010385double-stranded methylated DNA binding

Gene expression in normal tissue: MBD1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MBD1


DatabasePathway IDPathway Des.
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MBD1

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