MGST1
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:138330 Ensembl IDEnsembl:ENSG00000008394 HGNC IDHGNC:HGNC:7061 PHARMGKB IDPA30791 Map Location12p12.3 | |||||
GO terms in MGST1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IDA | GO:0004602 | glutathione peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: MGST1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MGST1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-4061 | glutathione-mediated detoxification |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MGST1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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