MKI67
Summary: This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| marker of proliferation Ki-67 | MIM:176741 | Ensembl:ENSG00000148773 | HGNC:HGNC:7107 | PA30825 | 10q26.2 |
Gene Categories:
TUMOR SUPPRESSORGO terms in MKI67
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0007088 | regulation of mitotic nuclear division |
| BP | ISS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0051983 | regulation of chromosome segregation |
| BP | ISS | GO:1902275 | regulation of chromatin organization |
| CC | IDA | GO:0000793 | condensed chromosome |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016604 | nuclear body |
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
Gene expression in normal tissue: MKI67
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MKI67
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MKI67
CLASSFICATION
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