MPP2
Summary: Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| membrane palmitoylated protein 2 | MIM:600723 | Ensembl:ENSG00000108852 | HGNC:HGNC:7220 | PA30925 | 17q21.31 |
Gene Categories:
KINASEGO terms in MPP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0032590 | dendrite membrane |
| CC | IEA | GO:0032591 | dendritic spine membrane |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | ISS | GO:0043198 | dendritic shaft |
| BP | ISS | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0060079 | excitatory postsynaptic potential |
| BP | ISS | GO:0060291 | long-term synaptic potentiation |
Gene expression in normal tissue: MPP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MPP2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MPP2
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