MTHFD2L
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | MIM:614047 | Ensembl:ENSG00000163738 | HGNC:HGNC:31865 | PA134943916 | 4q13.3 |
GO terms in MTHFD2L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
| MF | TAS | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity |
| MF | IBA | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| MF | TAS | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| MF | IBA | GO:0004488 | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| CC | IEA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005829 | cytosol |
| BP | IEA | GO:0000105 | histidine biosynthetic process |
| BP | IEA | GO:0006164 | purine nucleotide biosynthetic process |
| BP | IBA | GO:0006730 | one-carbon metabolic process |
| BP | IEA | GO:0009086 | methionine biosynthetic process |
| BP | IEA | GO:0009256 | 10-formyltetrahydrofolate metabolic process |
| BP | IBA | GO:0035999 | tetrahydrofolate interconversion |
| BP | IEA | GO:0035999 | tetrahydrofolate interconversion |
| BP | IBA | GO:0046653 | tetrahydrofolate metabolic process |
| BP | TAS | GO:0046655 | folic acid metabolic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
Gene expression in normal tissue: MTHFD2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MTHFD2L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2525 | Trans-sulfuration and one carbon metabolism |
| kegg | hsa00670 | One carbon pool by folate - Homo sapiens (human) |
| humancyc | PWY-2201 | folate transformations I |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196757 | Metabolism of folate and pterines |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MTHFD2L
CLASSFICATION
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