MARCH11
Summary: MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:613338 Ensembl IDEnsembl:ENSG00000183654 HGNC IDHGNC:HGNC:33609 PHARMGKB IDPA162395055 Map Location5p15.1 | |||||
GO terms in MARCH11
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0016567 | protein ubiquitination |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030659 | cytoplasmic vesicle membrane |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016740 | transferase activity |
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Gene expression in normal tissue: MARCH11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MARCH11
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MARCH11
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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