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MSI1

Summary: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
musashi RNA binding protein 1	MIM:603328	Ensembl:ENSG00000135097	HGNC:HGNC:7330	PA31137	12q24.31

GO terms in MSI1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	IBA	GO:0003723	RNA binding
MF	IEA	GO:0008266	poly(U) RNA binding
MF	IEA	GO:0042802	identical protein binding
BP	TAS	GO:0007399	nervous system development
BP	IBA	GO:0051252	regulation of RNA metabolic process
CC	IBA	GO:0005634	nucleus
CC	IEA	GO:0005634	nucleus
CC	IBA	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0005844	polysome
CC	IEA	GO:0005844	polysome

Gene expression in normal tissue: MSI1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSI1

Database	Pathway ID	Pathway Des.
kegg	hsa03015	mRNA surveillance pathway - Homo sapiens (human)
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-376176	Signaling by ROBO receptors
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-9010553	Regulation of expression of SLITs and ROBOs

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2
iGMDRD309	17AAG	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSI1

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CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.