MSI1
Summary: This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603328 Ensembl IDEnsembl:ENSG00000135097 HGNC IDHGNC:HGNC:7330 PHARMGKB IDPA31137 Map Location12q24.31 | |||||
GO terms in MSI1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IEA | GO:0008266 | poly(U) RNA binding |
| MF | IEA | GO:0042802 | identical protein binding |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IBA | GO:0051252 | regulation of RNA metabolic process |
Gene expression in normal tissue: MSI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MSI1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MSI1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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