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MSN

Summary: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
moesin	MIM:309845	Ensembl:ENSG00000147065	HGNC:HGNC:7373	PA31178	Xq12

Gene Categories:

CELL SURFACE

GO terms in MSN

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0001931	uropod
CC	HDA	GO:0005615	extracellular space
CC	HDA	GO:0005634	nucleus
CC	HDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005856	cytoskeleton
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005902	microvillus
CC	HDA	GO:0005925	focal adhesion
CC	IDA	GO:0005925	focal adhesion
CC	IDA	GO:0009986	cell surface
CC	IEA	GO:0016323	basolateral plasma membrane
CC	IDA	GO:0016324	apical plasma membrane
CC	IDA	GO:0030175	filopodium
CC	IDA	GO:0031143	pseudopodium
CC	IEA	GO:0031528	microvillus membrane
CC	HDA	GO:0031982	vesicle
CC	IEA	GO:0043209	myelin sheath
CC	IDA	GO:0045177	apical part of cell
CC	IDA	GO:0048471	perinuclear region of cytoplasm
CC	HDA	GO:0070062	extracellular exosome
CC	IDA	GO:0071437	invadopodium
CC	IDA	GO:0071944	cell periphery
CC	HDA	GO:0072562	blood microparticle
BP	IDA	GO:0001771	immunological synapse formation
BP	IEA	GO:0007010	cytoskeleton organization
BP	IEP	GO:0007159	leukocyte cell-cell adhesion
BP	IMP	GO:0008360	regulation of cell shape
BP	IMP	GO:0008361	regulation of cell size
BP	IMP	GO:0008361	regulation of cell size
BP	IGI	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0022612	gland morphogenesis
BP	IEP	GO:0022614	membrane to membrane docking
BP	TAS	GO:0035722	interleukin-12-mediated signaling pathway
BP	IDA	GO:0042098	T cell proliferation
BP	IMP	GO:0045198	establishment of epithelial cell apical/basal polarity
BP	IEP	GO:0050900	leukocyte migration
BP	IGI	GO:0061028	establishment of endothelial barrier
BP	IDA	GO:0070489	T cell aggregation
BP	IDA	GO:0071394	cellular response to testosterone stimulus
BP	IEA	GO:0071803	positive regulation of podosome assembly
BP	IDA	GO:0072678	T cell migration
BP	IGI	GO:1902115	regulation of organelle assembly
BP	IGI	GO:1902966	positive regulation of protein localization to early endosome
BP	IGI	GO:1903364	positive regulation of cellular protein catabolic process
BP	IMP	GO:2000401	regulation of lymphocyte migration
BP	IGI	GO:2000643	positive regulation of early endosome to late endosome transport
MF	IDA	GO:0003725	double-stranded RNA binding
MF	IEA	GO:0003779	actin binding
MF	IPI	GO:0005102	signaling receptor binding
MF	TAS	GO:0005200	structural constituent of cytoskeleton
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0019901	protein kinase binding
MF	IPI	GO:0050839	cell adhesion molecule binding

Gene expression in normal tissue: MSN

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSN

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-168256	Immune System
reactome	R-HSA-373760	L1CAM interactions
reactome	R-HSA-373760	L1CAM interactions
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-437239	Recycling pathway of L1
reactome	R-HSA-437239	Recycling pathway of L1
reactome	R-HSA-447115	Interleukin-12 family signaling
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-8950505	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
reactome	R-HSA-9020591	Interleukin-12 signaling
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_RAGE	RAGE
pid	er_nongenomic_pathway	Plasma membrane estrogen receptor signaling
pid	rhoa_pathway	RhoA signaling pathway
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)
kegg	hsa05162	Measles - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
wikipathways	WP2276	Glial Cell Differentiation
wikipathways	WP2324	AGE-RAGE pathway
wikipathways	WP4100	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
wikipathways	WP51	Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD144	NSC95397	3
iGMDRD670	ML 210	3
iGMDRD546	BMS-754807	3
iGMDRD779	PRL-3 Inhibitor I	1
iGMDRD150	RITA	3
iGMDRD781	Sirolimus	1
iGMDRD583	LDN 193189	1
iGMDRD494	Neopeltolide	4
iGMDRD330	BRD4132	3
iGMDRD76	Simvastatin	3
iGMDRD607	Ubistatin B	3
iGMDRD466	Chaetocin	4
iGMDRD394	BX-795	3
iGMDRD945	ML214	6
iGMDRD634	SCHEMBL2608041	1
iGMDRD434	BMS-536924	5
iGMDRD705	Nakiterpiosin	3
iGMDRD105	Triptolide	2
iGMDRD289	Parthenolide	3
iGMDRD294	Batimastat	3
iGMDRD138	PX 12	4
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD263	AACOCF3	6
iGMDRD887	Compound 23 citrate	3
iGMDRD872	BRD7137	3
iGMDRD286	Nsc 632839	3
iGMDRD188	Piperlongumine	1
iGMDRD398	Sepantronium	3
iGMDRD329	Merck60	3
iGMDRD662	JQ-1	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSN

SITE

DATATYPES

CLASSFICATION

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