MYH9
Summary: This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin heavy chain 9 | MIM:160775 | Ensembl:ENSG00000100345 | HGNC:HGNC:7579 | PA31377 | 22q12.3 |
Gene Categories:
CELL SURFACEGO terms in MYH9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000212 | meiotic spindle organization |
| BP | IDA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001768 | establishment of T cell polarity |
| BP | IDA | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | ISS | GO:0006911 | phagocytosis, engulfment |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007520 | myoblast fusion |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0015031 | protein transport |
| BP | IDA | GO:0030048 | actin filament-based movement |
| BP | IMP | GO:0030220 | platelet formation |
| BP | IEP | GO:0030224 | monocyte differentiation |
| BP | IDA | GO:0031032 | actomyosin structure organization |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IMP | GO:0032506 | cytokinetic process |
| BP | IEA | GO:0032796 | uropod organization |
| BP | IMP | GO:0043534 | blood vessel endothelial cell migration |
| BP | NAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051295 | establishment of meiotic spindle localization |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IMP | GO:1903919 | negative regulation of actin filament severing |
| BP | ISS | GO:1903919 | negative regulation of actin filament severing |
| BP | ISS | GO:1903923 | positive regulation of protein processing in phagocytic vesicle |
| CC | IDA | GO:0001725 | stress fiber |
| CC | IDA | GO:0001726 | ruffle |
| CC | IDA | GO:0001772 | immunological synapse |
| CC | IDA | GO:0001931 | uropod |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005826 | actomyosin contractile ring |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005903 | brush border |
| CC | IEA | GO:0005913 | cell-cell adherens junction |
| CC | ISS | GO:0005925 | focal adhesion |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IDA | GO:0008305 | integrin complex |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016460 | myosin II complex |
| CC | IDA | GO:0031252 | cell leading edge |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0042641 | actomyosin |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097513 | myosin II filament |
| MF | IDA | GO:0000146 | microfilament motor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | NAS | GO:0003774 | motor activity |
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | IDA | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0030898 | actin-dependent ATPase activity |
| MF | IDA | GO:0030898 | actin-dependent ATPase activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IMP | GO:0043495 | protein membrane anchor |
| MF | IDA | GO:0043531 | ADP binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | NAS | GO:0051015 | actin filament binding |
Gene expression in normal tissue: MYH9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYH9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD173 | Epothilone B | 1 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD652 | UNC0638 | 2 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD522 | ML-030 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD292 | NSC87877 | 1 |
| iGMDRD435 | BI-2536 | 7 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD511 | CHEMBL399379 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD151 | CHM-1 | 7 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD670 | ML 210 | 7 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYH9
CLASSFICATION
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