MYL6

Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemyosin light chain 6
OMIM IDMIM:609931
Ensembl IDEnsembl:ENSG00000092841
HGNC IDHGNC:HGNC:7587
PHARMGKB IDPA31384
Map Location12q13.2

GO terms in MYL6


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006936 muscle contraction
BP TAS GO:0007519 skeletal muscle tissue development
BP TAS GO:0030049 muscle filament sliding
CC TAS GO:0005829 cytosol
CC IDA GO:0005903 brush border
CC HDA GO:0016020 membrane
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Gene expression in normal tissue: MYL6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in MYL6


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-195258 RHO GTPase Effectors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

KRASKRASZNF273ZNF273PAX5PAX5CCDC117CCDC117SLC16A3SLC16A3NPAS2NPAS2RXRARXRAZFP36L2ZFP36L2RNU2-11PRNU2-11PAPOC1APOC1TCF7L2TCF7L2ZNF682ZNF682BRAFBRAFWDR24WDR24FERMT1FERMT1NHLRC1NHLRC1ZNF736ZNF736RN7SL477PRN7SL477PNRASNRASKLHL32KLHL32PD0325901PD0325901MYL6MYL6

Gene-drug targets distribution

Gene Structure: PDB

Models in MYL6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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