Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

myosin light chain 6MIM:609931Ensembl:ENSG00000092841HGNC:HGNC:7587PA3138412q13.2

GO terms in MYL6

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006936muscle contraction
BPTASGO:0007519skeletal muscle tissue development
BPTASGO:0030049muscle filament sliding
CCIDAGO:0005903brush border
CCTASGO:0016459myosin complex
CCTASGO:0016461unconventional myosin complex
CCHDAGO:0070062extracellular exosome
MFTASGO:0003774motor activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0008307structural constituent of muscle
MFISSGO:0030898actin-dependent ATPase activity

Gene expression in normal tissue: MYL6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYL6

DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625900RHO GTPases activate CIT
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYL6