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ACLY

Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ATP citrate lyase	MIM:108728	Ensembl:ENSG00000131473	HGNC:HGNC:115	PA24441	17q21.2

Gene Categories:

DRUGGABLE GENOME

GO terms in ACLY

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0003878	ATP citrate synthase activity
MF	IDA	GO:0003878	ATP citrate synthase activity
MF	TAS	GO:0003878	ATP citrate synthase activity
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0005524	ATP binding
MF	IEA	GO:0046872	metal ion binding
MF	IEA	GO:0048037	cofactor binding
CC	TAS	GO:0005576	extracellular region
CC	IDA	GO:0005654	nucleoplasm
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IBA	GO:0009346	citrate lyase complex
CC	HDA	GO:0016020	membrane
CC	TAS	GO:0035578	azurophil granule lumen
CC	HDA	GO:0070062	extracellular exosome
CC	TAS	GO:1904813	ficolin-1-rich granule lumen
BP	IBA	GO:0006085	acetyl-CoA biosynthetic process
BP	IDA	GO:0006085	acetyl-CoA biosynthetic process
BP	IDA	GO:0006101	citrate metabolic process
BP	IDA	GO:0006107	oxaloacetate metabolic process
BP	IBA	GO:0006633	fatty acid biosynthetic process
BP	TAS	GO:0006695	cholesterol biosynthetic process
BP	IDA	GO:0008610	lipid biosynthetic process
BP	TAS	GO:0015936	coenzyme A metabolic process
BP	TAS	GO:0031325	positive regulation of cellular metabolic process
BP	TAS	GO:0043312	neutrophil degranulation
BP	TAS	GO:0046949	fatty-acyl-CoA biosynthetic process

Gene expression in normal tissue: ACLY

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACLY

Database	Pathway ID	Pathway Des.
wikipathways	WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways	WP2453	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
wikipathways	WP357	Fatty Acid Biosynthesis
wikipathways	WP3925	Amino Acid metabolism
wikipathways	WP3965	Lipid Metabolism Pathway
wikipathways	WP4010	Liver steatosis AOP
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
smpdb	SMP00466	Transfer of Acetyl Groups into Mitochondria
smpdb	SMP02298	Glutaminolysis and Cancer
humancyc	PWY-5172	acetyl-CoA biosynthesis from citrate
netpath	Pathway_TCR	TCR
kegg	hsa00020	Citrate cycle (TCA cycle) - Homo sapiens (human)
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-163685	Integration of energy metabolism
reactome	R-HSA-163765	ChREBP activates metabolic gene expression
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-6798695	Neutrophil degranulation
reactome	R-HSA-75105	Fatty acyl-CoA biosynthesis
reactome	R-HSA-8978868	Fatty acid metabolism

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACLY

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DATATYPES

CLASSFICATION

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