NEUROD1


Summary: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601724
PHARMGKB IDPA31564
Map Location2q31.3

GO terms in NEUROD1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IC GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005737 cytoplasm
CC IDA GO:0090575 RNA polymerase II transcription factor complex
BP IEA GO:0003326 pancreatic A cell fate commitment
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Gene expression in normal tissue: NEUROD1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in NEUROD1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-186712 Regulation of beta-cell development
reactome R-HSA-186712 Regulation of beta-cell development
reactome R-HSA-210745 Regulation of gene expression in beta cells
reactome R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEUROD1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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