NFATC4
Summary: This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear factor of activated T cells 4 | MIM:602699 | Ensembl:ENSG00000100968 | HGNC:HGNC:7778 | PA31584 | 14q12 |
GO terms in NFATC4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IGI | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0042975 | peroxisome proliferator activated receptor binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IBA | GO:0044798 | nuclear transcription factor complex |
| BP | IEA | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | IBA | GO:0001816 | cytokine production |
| BP | IBA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IEA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IBA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IEA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IEA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035562 | negative regulation of chromatin binding |
| BP | IEA | GO:0045333 | cellular respiration |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0050774 | negative regulation of dendrite morphogenesis |
| BP | IEA | GO:0051145 | smooth muscle cell differentiation |
| BP | IEA | GO:0055001 | muscle cell development |
| BP | IEA | GO:0071285 | cellular response to lithium ion |
| BP | IGI | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IEA | GO:1904637 | cellular response to ionomycin |
| BP | IEA | GO:2000297 | negative regulation of synapse maturation |
| BP | IEA | GO:2001235 | positive regulation of apoptotic signaling pathway |
Gene expression in normal tissue: NFATC4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NFATC4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NFATC4
CLASSFICATION
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