Summary: This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

nuclear factor of activated T cells 4MIM:602699Ensembl:ENSG00000100968HGNC:HGNC:7778PA3158414q12

GO terms in NFATC4

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIGIGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIBAGO:0003682chromatin binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIEAGO:0008134transcription factor binding
MFIEAGO:0042975peroxisome proliferator activated receptor binding
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005667transcription factor complex
CCIDAGO:0016607nuclear speck
CCIBAGO:0044798nuclear transcription factor complex
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIBAGO:0001816cytokine production
BPIBAGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006954inflammatory response
BPIEAGO:0007507heart development
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0030178negative regulation of Wnt signaling pathway
BPIEAGO:0032091negative regulation of protein binding
BPIEAGO:0032760positive regulation of tumor necrosis factor production
BPIBAGO:0033173calcineurin-NFAT signaling cascade
BPIEAGO:0033173calcineurin-NFAT signaling cascade
BPIEAGO:0034644cellular response to UV
BPIEAGO:0035562negative regulation of chromatin binding
BPIEAGO:0045333cellular respiration
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048167regulation of synaptic plasticity
BPIEAGO:0050774negative regulation of dendrite morphogenesis
BPIEAGO:0051145smooth muscle cell differentiation
BPIEAGO:0055001muscle cell development
BPIEAGO:0071285cellular response to lithium ion
BPIGIGO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II
BPIEAGO:1904637cellular response to ionomycin
BPIEAGO:2000297negative regulation of synapse maturation
BPIEAGO:2001235positive regulation of apoptotic signaling pathway

Gene expression in normal tissue: NFATC4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NFATC4

DatabasePathway IDPathway Des.
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1591Heart Development
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP428Wnt Signaling Pathway
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFATC4