ATP1A3


Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

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GO terms in ATP1A3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005783 endoplasmic reticulum
CC IDA GO:0005794 Golgi apparatus
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IC GO:0005890 sodium:potassium-exchanging ATPase complex
CC IDA GO:0005890 sodium:potassium-exchanging ATPase complex
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Gene expression in normal tissue: ATP1A3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP1A3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-5576891 Cardiac conduction
reactome R-HSA-5578775 Ion homeostasis
reactome R-HSA-936837 Ion transport by P-type ATPases
reactome R-HSA-983712 Ion channel transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP1A3

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Cancer
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