ATP1A3
Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:182350 Ensembl IDEnsembl:ENSG00000105409 HGNC IDHGNC:HGNC:801 PHARMGKB IDPA64 Map Location19q13.2 |
GO terms in ATP1A3
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005783 | endoplasmic reticulum |
CC | IDA | GO:0005794 | Golgi apparatus |
CC | IDA | GO:0005886 | plasma membrane |
CC | TAS | GO:0005886 | plasma membrane |
CC | IC | GO:0005890 | sodium:potassium-exchanging ATPase complex |
CC | IDA | GO:0005890 | sodium:potassium-exchanging ATPase complex |
Gene expression in normal tissue: ATP1A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP1A3
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-382551 | Transport of small molecules |
reactome | R-HSA-397014 | Muscle contraction |
reactome | R-HSA-5576891 | Cardiac conduction |
reactome | R-HSA-5578775 | Ion homeostasis |
reactome | R-HSA-936837 | Ion transport by P-type ATPases |
reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ATP1A3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |