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TONSL

Summary: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
tonsoku like, DNA repair protein	MIM:604546	Ensembl:ENSG00000160949	HGNC:HGNC:7801	PA31605	8q24.3

Gene Categories:

DNA REPAIR

GO terms in TONSL

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0003714	transcription corepressor activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0042393	histone binding
BP	IMP	GO:0000724	double-strand break repair via homologous recombination
BP	IMP	GO:0031297	replication fork processing
BP	TAS	GO:0042994	cytoplasmic sequestering of transcription factor
BP	IEA	GO:1903507	negative regulation of nucleic acid-templated transcription
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0005662	DNA replication factor A complex
CC	IEA	GO:0005737	cytoplasm
CC	IDA	GO:0016604	nuclear body
CC	IDA	GO:0035101	FACT complex
CC	IDA	GO:0042555	MCM complex
CC	IDA	GO:0043596	nuclear replication fork

Gene expression in normal tissue: TONSL

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TONSL

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TONSL

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DATATYPES

CLASSFICATION

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