SEARCH

HOME / SEARCH / TONSL

TONSL

Summary: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametonsoku like, DNA repair protein OMIM IDMIM:604546 Ensembl IDEnsembl:ENSG00000160949 HGNC IDHGNC:HGNC:7801 PHARMGKB IDPA31605 Map Location8q24.3

Gene Categories:

DNA REPAIR

GO terms in TONSL

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0003714	transcription corepressor activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0042393	histone binding
BP	IMP	GO:0000724	double-strand break repair via homologous recombination
BP	IMP	GO:0031297	replication fork processing
BP	TAS	GO:0042994	cytoplasmic sequestering of transcription factor

Showing 1 to 6 of 14 rows rows per page

Gene expression in normal tissue: TONSL

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TONSL

Loading, please wait...

Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TONSL

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.