NPAS2

Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameneuronal PAS domain protein 2
OMIM IDMIM:603347
Ensembl IDEnsembl:ENSG00000170485
HGNC IDHGNC:HGNC:7895
PHARMGKB IDPA31696
Map Location2q11.2

GO terms in NPAS2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0003677 DNA binding
MF IPI GO:0003677 DNA binding
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Gene expression in normal tissue: NPAS2

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in NPAS2


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Database
Pathway ID
Pathway Des.
kegg hsa04710 Circadian rhythm - Homo sapiens (human)
pid circadianpathway Circadian rhythm pathway
wikipathways WP1797 Circadian Clock
wikipathways WP2797 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathways WP3370 RORA activates gene expression
wikipathways WP3394 NR1D1 (REV-ERBA) represses gene expression
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NPAS2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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