ATP2A1


Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in ATP2A1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005388 calcium-transporting ATPase activity
MF IDA GO:0005388 calcium-transporting ATPase activity
MF TAS GO:0005388 calcium-transporting ATPase activity
MF IMP GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
Showing 1 to 6 of 35 rows rows per page

Gene expression in normal tissue: ATP2A1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Pathways in ATP2A1


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1912420 Pre-NOTCH Processing in Golgi
reactome R-HSA-1912422 Pre-NOTCH Expression and Processing
reactome R-HSA-382551 Transport of small molecules
Showing 1 to 6 of 22 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP2A1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​