NT5E

Summary: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Name5'-nucleotidase ecto
OMIM IDMIM:129190
Ensembl IDEnsembl:ENSG00000135318
HGNC IDHGNC:HGNC:8021
PHARMGKB IDPA31804
Map Location6q14.3

GO terms in NT5E


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000166 nucleotide binding
MF EXP GO:0008253 5'-nucleotidase activity
MF IDA GO:0008253 5'-nucleotidase activity
MF IEA GO:0046872 metal ion binding
BP TAS GO:0006195 purine nucleotide catabolic process
BP IEA GO:0006196 AMP catabolic process
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Gene expression in normal tissue: NT5E

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

EGFR signaling1ERK MAPK signaling1

Pathways in NT5E


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-15869 Metabolism of nucleotides
reactome R-HSA-196807 Nicotinate metabolism
reactome R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
reactome R-HSA-196854 Metabolism of vitamins and cofactors
reactome R-HSA-73621 Pyrimidine catabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
iGMDRD792 Cetuximab 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NT5E

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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