Summary: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].

neurotrophin 3MIM:162660Ensembl:ENSG00000185652HGNC:HGNC:8023PA3180612p13.31

GO terms in NTF3

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIBAGO:0008021synaptic vesicle
CCIBAGO:0031410cytoplasmic vesicle
BPIDAGO:0000187activation of MAPK activity
BPIDAGO:0002092positive regulation of receptor internalization
BPTASGO:0007165signal transduction
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIDAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0007267cell-cell signaling
BPTASGO:0007267cell-cell signaling
BPTASGO:0007399nervous system development
BPIBAGO:0007422peripheral nervous system development
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0021675nerve development
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0032148activation of protein kinase B activity
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIBAGO:0038180nerve growth factor signaling pathway
BPIGIGO:0042981regulation of apoptotic process
BPIBAGO:0043524negative regulation of neuron apoptotic process
BPIBAGO:0045664regulation of neuron differentiation
BPIBAGO:0048812neuron projection morphogenesis
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050732negative regulation of peptidyl-tyrosine phosphorylation
BPIBAGO:0050804modulation of chemical synaptic transmission
BPIEAGO:0050918positive chemotaxis
BPIDAGO:0050930induction of positive chemotaxis
BPIDAGO:0090630activation of GTPase activity
BPIDAGO:2000251positive regulation of actin cytoskeleton reorganization
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008083growth factor activity
MFIDAGO:0042056chemoattractant activity

Gene expression in normal tissue: NTF3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NTF3

DatabasePathway IDPathway Des.
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidshp2_pathwaySHP2 signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9025046NTF3 activates NTRK2 (TRKB) signaling
reactomeR-HSA-9034013NTF3 activates NTRK3 signaling
reactomeR-HSA-9034013NTF3 activates NTRK3 signaling
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034793Activated NTRK3 signals through PLCG1
reactomeR-HSA-9034793Activated NTRK3 signals through PLCG1
reactomeR-HSA-9034864Activated NTRK3 signals through RAS
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
biocartaerk5pathwayrole of erk5 in neuronal survival pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NTF3