NTF3
Summary: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameneurotrophin 3 OMIM IDMIM:162660 Ensembl IDEnsembl:ENSG00000185652 HGNC IDHGNC:HGNC:8023 PHARMGKB IDPA31806 Map Location12p13.31 | |||||
GO terms in NTF3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IBA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0030424 | axon |
| CC | IBA | GO:0030425 | dendrite |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
Gene expression in normal tissue: NTF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NTF3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NTF3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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