ATP2B4
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:108732 Ensembl IDEnsembl:ENSG00000058668 HGNC IDHGNC:HGNC:817 PHARMGKB IDPA25110 Map Location1q32.1 | |||||
GO terms in ATP2B4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0003407 | neural retina development |
| BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006874 | cellular calcium ion homeostasis |
| BP | IC | GO:0006874 | cellular calcium ion homeostasis |
| BP | IDA | GO:0006874 | cellular calcium ion homeostasis |
| BP | ISS | GO:0006874 | cellular calcium ion homeostasis |
Gene expression in normal tissue: ATP2B4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ATP2B4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418359 | Reduction of cytosolic Ca++ levels |
| reactome | R-HSA-418360 | Platelet calcium homeostasis |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ATP2B4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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