Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

ATPase plasma membrane Ca2+ transporting 4MIM:108732Ensembl:ENSG00000058668HGNC:HGNC:817PA251101q32.1

GO terms in ATP2B4

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0003407neural retina development
BPIMPGO:0006357regulation of transcription by RNA polymerase II
BPIBAGO:0006874cellular calcium ion homeostasis
BPICGO:0006874cellular calcium ion homeostasis
BPIDAGO:0006874cellular calcium ion homeostasis
BPISSGO:0006874cellular calcium ion homeostasis
BPIDAGO:0010751negative regulation of nitric oxide mediated signal transduction
BPIEAGO:0021766hippocampus development
BPISSGO:0030317flagellated sperm motility
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPTASGO:0034220ion transmembrane transport
BPIDAGO:0045019negative regulation of nitric oxide biosynthetic process
BPIDAGO:0051001negative regulation of nitric-oxide synthase activity
BPIBAGO:0051480regulation of cytosolic calcium ion concentration
BPIMPGO:0051599response to hydrostatic pressure
BPIMPGO:0070588calcium ion transmembrane transport
BPIDAGO:0070885negative regulation of calcineurin-NFAT signaling cascade
BPIDAGO:0071872cellular response to epinephrine stimulus
BPICGO:0097553calcium ion transmembrane import into cytosol
BPICGO:0098703calcium ion import across plasma membrane
BPIDAGO:0098736negative regulation of the force of heart contraction
BPIEAGO:0099132ATP hydrolysis coupled cation transmembrane transport
BPIDAGO:0140199negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
BPIDAGO:1900082negative regulation of arginine catabolic process
BPIEAGO:1901660calcium ion export
BPNASGO:1902083negative regulation of peptidyl-cysteine S-nitrosylation
BPICGO:1902305regulation of sodium ion transmembrane transport
BPIMPGO:1902806regulation of cell cycle G1/S phase transition
BPIMPGO:1903243negative regulation of cardiac muscle hypertrophy in response to stress
BPIDAGO:1903249negative regulation of citrulline biosynthetic process
BPTASGO:1903779regulation of cardiac conduction
BPIDAGO:2000481positive regulation of cAMP-dependent protein kinase activity
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0016323basolateral plasma membrane
CCIDAGO:0030018Z disc
CCISSGO:0032991protein-containing complex
CCISSGO:0036126sperm flagellum
CCIEAGO:0043005neuron projection
CCIBAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0097228sperm principal piece
MFIBAGO:0005388calcium-transporting ATPase activity
MFIMPGO:0005388calcium-transporting ATPase activity
MFTASGO:0005388calcium-transporting ATPase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFISSGO:0017080sodium channel regulator activity
MFIBAGO:0019829cation-transporting ATPase activity
MFIEAGO:0019901protein kinase binding
MFIBAGO:0030165PDZ domain binding
MFIDAGO:0030346protein phosphatase 2B binding
MFIDAGO:0036487nitric-oxide synthase inhibitor activity
MFIDAGO:0036487nitric-oxide synthase inhibitor activity
MFIEAGO:0046872metal ion binding
MFIPIGO:0050998nitric-oxide synthase binding
MFISSGO:0097110scaffold protein binding

Gene expression in normal tissue: ATP2B4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATP2B4

DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418359Reduction of cytosolic Ca++ levels
reactomeR-HSA-418360Platelet calcium homeostasis
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP2B4