Summary: The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013].

purinergic receptor P2X 1MIM:600845Ensembl:ENSG00000108405HGNC:HGNC:8533PA3286117p13.2

GO terms in P2RX1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001614purinergic nucleotide receptor activity
MFIDAGO:0001614purinergic nucleotide receptor activity
MFIBAGO:0004931extracellularly ATP-gated cation channel activity
MFIDAGO:0005261cation channel activity
MFIEAGO:0005524ATP binding
MFIEAGO:0008270zinc ion binding
MFIBAGO:0035381ATP-gated ion channel activity
CCIBAGO:0005639integral component of nuclear inner membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0005887integral component of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIBAGO:0016021integral component of membrane
CCTASGO:0030667secretory granule membrane
CCIEAGO:0032991protein-containing complex
CCTASGO:0035579specific granule membrane
CCIEAGO:0043005neuron projection
CCIEAGO:0045121membrane raft
CCIEAGO:0045211postsynaptic membrane
BPIEAGO:0002554serotonin secretion by platelet
BPIEAGO:0003056regulation of vascular smooth muscle contraction
BPIDAGO:0006811ion transport
BPIBAGO:0006812cation transport
BPIEAGO:0006915apoptotic process
BPIEAGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0007165signal transduction
BPTASGO:0007596blood coagulation
BPIEAGO:0008217regulation of blood pressure
BPIEAGO:0019228neuronal action potential
BPIEAGO:0030168platelet activation
BPIEAGO:0033198response to ATP
BPIBAGO:0034220ion transmembrane transport
BPIEAGO:0035249synaptic transmission, glutamatergic
BPIEAGO:0035590purinergic nucleotide receptor signaling pathway
BPIEAGO:0043270positive regulation of ion transport
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0046513ceramide biosynthetic process
BPIEAGO:0051260protein homooligomerization
BPIEAGO:0051291protein heterooligomerization
BPIEAGO:0051924regulation of calcium ion transport
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0098655cation transmembrane transport

Gene expression in normal tissue: P2RX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in P2RX1

DatabasePathway IDPathway Des.
pharmgkbPA154444041Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
reactomeR-HSA-139853Elevation of cytosolic Ca2+ levels
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418360Platelet calcium homeostasis
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in P2RX1