P2RX7


Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
purinergic receptor P2X 7MIM:602566Ensembl:ENSG00000089041HGNC:HGNC:8537PA3286612q24.31

GO terms in P2RX7


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001530lipopolysaccharide binding
MFIBAGO:0001614purinergic nucleotide receptor activity
MFIDAGO:0001614purinergic nucleotide receptor activity
MFIBAGO:0004931extracellularly ATP-gated cation channel activity
MFIDAGO:0004931extracellularly ATP-gated cation channel activity
MFTASGO:0004931extracellularly ATP-gated cation channel activity
MFISSGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFICGO:0005524ATP binding
MFIBAGO:0035381ATP-gated ion channel activity
MFNASGO:0042803protein homodimerization activity
BPIEAGO:0000187activation of MAPK activity
BPIEAGO:0000902cell morphogenesis
BPIEAGO:0001845phagolysosome assembly
BPIEAGO:0001916positive regulation of T cell mediated cytotoxicity
BPISSGO:0002028regulation of sodium ion transport
BPIEAGO:0006468protein phosphorylation
BPIEAGO:0006509membrane protein ectodomain proteolysis
BPIEAGO:0006649phospholipid transfer to membrane
BPIBAGO:0006812cation transport
BPIEAGO:0006900vesicle budding from membrane
BPIEAGO:0006954inflammatory response
BPIEAGO:0007005mitochondrion organization
BPISSGO:0007166cell surface receptor signaling pathway
BPTASGO:0007596blood coagulation
BPIEAGO:0009612response to mechanical stimulus
BPIEAGO:0010043response to zinc ion
BPIDAGO:0010524positive regulation of calcium ion transport into cytosol
BPIMPGO:0010628positive regulation of gene expression
BPIEAGO:0014049positive regulation of glutamate secretion
BPIEAGO:0014054positive regulation of gamma-aminobutyric acid secretion
BPIEAGO:0016079synaptic vesicle exocytosis
BPIEAGO:0016485protein processing
BPIDAGO:0017121phospholipid scrambling
BPISSGO:0019233sensory perception of pain
BPIEAGO:0019835cytolysis
BPIEAGO:0030163protein catabolic process
BPISSGO:0030501positive regulation of bone mineralization
BPIEAGO:0031668cellular response to extracellular stimulus
BPIDAGO:0032060bleb assembly
BPISSGO:0032060bleb assembly
BPIEAGO:0032308positive regulation of prostaglandin secretion
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIEAGO:0032963collagen metabolic process
BPIDAGO:0033198response to ATP
BPIBAGO:0034220ion transmembrane transport
BPIEAGO:0034405response to fluid shear stress
BPIMPGO:0034767positive regulation of ion transmembrane transport
BPIMPGO:0035590purinergic nucleotide receptor signaling pathway
BPIEAGO:0042098T cell proliferation
BPIEAGO:0043029T cell homeostasis
BPIEAGO:0043132NAD transport
BPISSGO:0043409negative regulation of MAPK cascade
BPIEAGO:0045332phospholipid translocation
BPISSGO:0045779negative regulation of bone resorption
BPIMPGO:0045794negative regulation of cell volume
BPIMPGO:0045821positive regulation of glycolytic process
BPISSGO:0045919positive regulation of cytolysis
BPIEAGO:0046513ceramide biosynthetic process
BPIDAGO:0046931pore complex assembly
BPIMPGO:0046931pore complex assembly
BPIEAGO:0048705skeletal system morphogenesis
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIEAGO:0050717positive regulation of interleukin-1 alpha secretion
BPIDAGO:0050718positive regulation of interleukin-1 beta secretion
BPIEAGO:0050830defense response to Gram-positive bacterium
BPIEAGO:0051209release of sequestered calcium ion into cytosol
BPIEAGO:0051259protein complex oligomerization
BPISSGO:0051495positive regulation of cytoskeleton organization
BPIEAGO:0051592response to calcium ion
BPIEAGO:0051602response to electrical stimulus
BPNASGO:0051709regulation of killing of cells of other organism
BPIDAGO:0051899membrane depolarization
BPIEAGO:0051901positive regulation of mitochondrial depolarization
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0070230positive regulation of lymphocyte apoptotic process
BPIEAGO:0071359cellular response to dsRNA
BPIEAGO:0072593reactive oxygen species metabolic process
BPISSGO:0097190apoptotic signaling pathway
BPIEAGO:0097191extrinsic apoptotic signaling pathway
BPIMPGO:1904172positive regulation of bleb assembly
CCIBAGO:0005639integral component of nuclear inner membrane
CCISSGO:0005737cytoplasm
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCICGO:0005887integral component of plasma membrane
CCIEAGO:0005911cell-cell junction
CCIEAGO:0009897external side of plasma membrane
CCIDAGO:0016020membrane
CCIBAGO:0016021integral component of membrane
CCIEAGO:0031594neuromuscular junction
CCISSGO:0032059bleb
CCIEAGO:0043025neuronal cell body
CCIEAGO:0098793presynapse
CCIEAGO:0098794postsynapse

Gene expression in normal tissue: P2RX7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in P2RX7


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-139853Elevation of cytosolic Ca2+ levels
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418360Platelet calcium homeostasis
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-844456The NLRP3 inflammasome
reactomeR-HSA-844456The NLRP3 inflammasome
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD171Pemetrexed2
iGMDRD226ML0062
iGMDRD187BRD98762
iGMDRD260FQI-21
iGMDRD64Parbendazole6
iGMDRD23Gossypol3
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin3
iGMDRD506Fedratinib2
iGMDRD888Compound 442
iGMDRD780PP-303
iGMDRD779PRL-3 Inhibitor I2
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib6
iGMDRD151CHM-12
iGMDRD433Lexibulin5
iGMDRD466Chaetocin1
iGMDRD639YK 4-2792
iGMDRD61Kinetin riboside2
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin2
iGMDRD137Indisulam6
iGMDRD158NSC1415402
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16753
iGMDRD871BRD63682
iGMDRD329Merck603
iGMDRD405PIK-751
iGMDRD123Isoevodiamine6
iGMDRD154NSC237662
iGMDRD341Triacsin c2
iGMDRD237ABT-7511
iGMDRD441TW 372
iGMDRD138PX 123
iGMDRD255SB2250021
iGMDRD8024-methylfasudil3
iGMDRD60Quinoclamine2
iGMDRD451Serdemetan2
iGMDRD100Zebularine3
iGMDRD562Navitoclax5
iGMDRD554CHEMBL14341372
iGMDRD599Salermide1
iGMDRD1008SR-II-138A2
iGMDRD579PF7503
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B2
iGMDRD634SCHEMBL26080413
iGMDRD446LY 21832403
iGMDRD193Fqi15
iGMDRD6AM-5808
iGMDRD434BMS-5369245
iGMDRD267Oligomycin A5
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib5
iGMDRD82Quiflapon3
iGMDRD872BRD71375
iGMDRD116CD4372
iGMDRD424Tamatinib3
iGMDRD84Lovastatin acid2
iGMDRD512nutlin 32
iGMDRD901ELCPK3
iGMDRD85Ursolic acid2
iGMDRD351GW843682X2
iGMDRD57Chloropentafluorobenzene5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in P2RX7

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