P2RX7
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602566 Ensembl IDEnsembl:ENSG00000089041 HGNC IDHGNC:HGNC:8537 PHARMGKB IDPA32866 Map Location12q24.31 | |||||
GO terms in P2RX7
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001530 | lipopolysaccharide binding |
| MF | IBA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IDA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IBA | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | IDA | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | TAS | GO:0004931 | extracellularly ATP-gated cation channel activity |
Gene expression in normal tissue: P2RX7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P2RX7
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-139853 | Elevation of cytosolic Ca2+ levels |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P2RX7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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