P2RX7
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| purinergic receptor P2X 7 | MIM:602566 | Ensembl:ENSG00000089041 | HGNC:HGNC:8537 | PA32866 | 12q24.31 |
GO terms in P2RX7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001530 | lipopolysaccharide binding |
| MF | IBA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IDA | GO:0001614 | purinergic nucleotide receptor activity |
| MF | IBA | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | IDA | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | TAS | GO:0004931 | extracellularly ATP-gated cation channel activity |
| MF | ISS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IC | GO:0005524 | ATP binding |
| MF | IBA | GO:0035381 | ATP-gated ion channel activity |
| MF | NAS | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001845 | phagolysosome assembly |
| BP | IEA | GO:0001916 | positive regulation of T cell mediated cytotoxicity |
| BP | ISS | GO:0002028 | regulation of sodium ion transport |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006509 | membrane protein ectodomain proteolysis |
| BP | IEA | GO:0006649 | phospholipid transfer to membrane |
| BP | IBA | GO:0006812 | cation transport |
| BP | IEA | GO:0006900 | vesicle budding from membrane |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0007005 | mitochondrion organization |
| BP | ISS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0010043 | response to zinc ion |
| BP | IDA | GO:0010524 | positive regulation of calcium ion transport into cytosol |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0014049 | positive regulation of glutamate secretion |
| BP | IEA | GO:0014054 | positive regulation of gamma-aminobutyric acid secretion |
| BP | IEA | GO:0016079 | synaptic vesicle exocytosis |
| BP | IEA | GO:0016485 | protein processing |
| BP | IDA | GO:0017121 | phospholipid scrambling |
| BP | ISS | GO:0019233 | sensory perception of pain |
| BP | IEA | GO:0019835 | cytolysis |
| BP | IEA | GO:0030163 | protein catabolic process |
| BP | ISS | GO:0030501 | positive regulation of bone mineralization |
| BP | IEA | GO:0031668 | cellular response to extracellular stimulus |
| BP | IDA | GO:0032060 | bleb assembly |
| BP | ISS | GO:0032060 | bleb assembly |
| BP | IEA | GO:0032308 | positive regulation of prostaglandin secretion |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IEA | GO:0032963 | collagen metabolic process |
| BP | IDA | GO:0033198 | response to ATP |
| BP | IBA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0034405 | response to fluid shear stress |
| BP | IMP | GO:0034767 | positive regulation of ion transmembrane transport |
| BP | IMP | GO:0035590 | purinergic nucleotide receptor signaling pathway |
| BP | IEA | GO:0042098 | T cell proliferation |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | IEA | GO:0043132 | NAD transport |
| BP | ISS | GO:0043409 | negative regulation of MAPK cascade |
| BP | IEA | GO:0045332 | phospholipid translocation |
| BP | ISS | GO:0045779 | negative regulation of bone resorption |
| BP | IMP | GO:0045794 | negative regulation of cell volume |
| BP | IMP | GO:0045821 | positive regulation of glycolytic process |
| BP | ISS | GO:0045919 | positive regulation of cytolysis |
| BP | IEA | GO:0046513 | ceramide biosynthetic process |
| BP | IDA | GO:0046931 | pore complex assembly |
| BP | IMP | GO:0046931 | pore complex assembly |
| BP | IEA | GO:0048705 | skeletal system morphogenesis |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IEA | GO:0050717 | positive regulation of interleukin-1 alpha secretion |
| BP | IDA | GO:0050718 | positive regulation of interleukin-1 beta secretion |
| BP | IEA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IEA | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051259 | protein complex oligomerization |
| BP | ISS | GO:0051495 | positive regulation of cytoskeleton organization |
| BP | IEA | GO:0051592 | response to calcium ion |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | NAS | GO:0051709 | regulation of killing of cells of other organism |
| BP | IDA | GO:0051899 | membrane depolarization |
| BP | IEA | GO:0051901 | positive regulation of mitochondrial depolarization |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0070230 | positive regulation of lymphocyte apoptotic process |
| BP | IEA | GO:0071359 | cellular response to dsRNA |
| BP | IEA | GO:0072593 | reactive oxygen species metabolic process |
| BP | ISS | GO:0097190 | apoptotic signaling pathway |
| BP | IEA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:1904172 | positive regulation of bleb assembly |
| CC | IBA | GO:0005639 | integral component of nuclear inner membrane |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IC | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | ISS | GO:0032059 | bleb |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0098793 | presynapse |
| CC | IEA | GO:0098794 | postsynapse |
Gene expression in normal tissue: P2RX7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in P2RX7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-139853 | Elevation of cytosolic Ca2+ levels |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418360 | Platelet calcium homeostasis |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-622312 | Inflammasomes |
| reactome | R-HSA-844456 | The NLRP3 inflammasome |
| reactome | R-HSA-844456 | The NLRP3 inflammasome |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD6 | AM-580 | 8 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in P2RX7
CLASSFICATION
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