CD207
Summary: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameCD207 molecule OMIM IDMIM:604862 Ensembl IDEnsembl:ENSG00000116031 HGNC IDHGNC:HGNC:17935 PHARMGKB IDPA134986203 Map Location2p13.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CD207
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005537 | mannose binding |
| MF | IDA | GO:0030246 | carbohydrate binding |
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | IDA | GO:0051607 | defense response to virus |
Gene expression in normal tissue: CD207
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD207
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD207
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.