PRDX1
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| peroxiredoxin 1 | MIM:176763 | Ensembl:ENSG00000117450 | HGNC:HGNC:9352 | PA33722 | 1p34.1 |
GO terms in PRDX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004601 | peroxidase activity |
| MF | TAS | GO:0004601 | peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0008379 | thioredoxin peroxidase activity |
| MF | IBA | GO:0008379 | thioredoxin peroxidase activity |
| MF | IDA | GO:0008379 | thioredoxin peroxidase activity |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| CC | HDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | HEP | GO:0001895 | retina homeostasis |
| BP | IBA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0019430 | removal of superoxide radicals |
| BP | IDA | GO:0030101 | natural killer cell activation |
| BP | IEA | GO:0032872 | regulation of stress-activated MAPK cascade |
| BP | IEA | GO:0034101 | erythrocyte homeostasis |
| BP | TAS | GO:0034599 | cellular response to oxidative stress |
| BP | IEA | GO:0042267 | natural killer cell mediated cytotoxicity |
| BP | IBA | GO:0042744 | hydrogen peroxide catabolic process |
| BP | IDA | GO:0042744 | hydrogen peroxide catabolic process |
| BP | IBA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:1901222 | regulation of NIK/NF-kappaB signaling |
Gene expression in normal tissue: PRDX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| kegg | hsa04146 | Peroxisome - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRDX1
CLASSFICATION
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