PRDX1
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameperoxiredoxin 1 OMIM IDMIM:176763 Ensembl IDEnsembl:ENSG00000117450 HGNC IDHGNC:HGNC:9352 PHARMGKB IDPA33722 Map Location1p34.1 | |||||
GO terms in PRDX1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004601 | peroxidase activity |
| MF | TAS | GO:0004601 | peroxidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0008379 | thioredoxin peroxidase activity |
| MF | IBA | GO:0008379 | thioredoxin peroxidase activity |
Gene expression in normal tissue: PRDX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDX1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3299685 | Detoxification of Reactive Oxygen Species |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRDX1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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