KCNK4


Summary: This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in KCNK4


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IMP GO:0005887 integral component of plasma membrane
CC ISS GO:0005887 integral component of plasma membrane
CC IDA GO:0034705 potassium channel complex
BP TAS GO:0006813 potassium ion transport
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Gene expression in normal tissue: KCNK4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1Protein stability and degradation1

Pathways in KCNK4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296071 Potassium Channels
reactome R-HSA-1296346 Tandem pore domain potassium channels
reactome R-HSA-1299503 TWIK related potassium channel (TREK)
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-5576886 Phase 4 - resting membrane potential
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNK4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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