KCNK4
Summary: This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium two pore domain channel subfamily K member 4 | MIM:605720 | Ensembl:ENSG00000182450 | HGNC:HGNC:6279 | PA30061 | 11q13.1 |
GO terms in KCNK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IMP | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0034705 | potassium channel complex |
| BP | TAS | GO:0006813 | potassium ion transport |
| BP | IEA | GO:0007613 | memory |
| BP | ISS | GO:0019233 | sensory perception of pain |
| BP | IBA | GO:0030322 | stabilization of membrane potential |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | ISS | GO:0050951 | sensory perception of temperature stimulus |
| BP | ISS | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch |
| BP | IDA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IDA | GO:0071398 | cellular response to fatty acid |
| BP | ISS | GO:0071469 | cellular response to alkaline pH |
| BP | ISS | GO:0071502 | cellular response to temperature stimulus |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IDA | GO:0071805 | potassium ion transmembrane transport |
| MF | IEA | GO:0005244 | voltage-gated ion channel activity |
| MF | IDA | GO:0005267 | potassium channel activity |
| MF | IBA | GO:0022841 | potassium ion leak channel activity |
| MF | ISS | GO:0097604 | temperature-gated cation channel activity |
| MF | IDA | GO:0098782 | mechanosensitived potassium channel activity |
Gene expression in normal tissue: KCNK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296346 | Tandem pore domain potassium channels |
| reactome | R-HSA-1299503 | TWIK related potassium channel (TREK) |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576886 | Phase 4 - resting membrane potential |
| reactome | R-HSA-5576891 | Cardiac conduction |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNK4
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