PCDH8


Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protocadherin 8MIM:603580Ensembl:ENSG00000136099HGNC:HGNC:8660PA3300713q14.3

GO terms in PCDH8


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005509calcium ion binding
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030425dendrite
CCIEAGO:0042734presynaptic membrane
CCIEAGO:0045211postsynaptic membrane
BPIEAGO:0001756somitogenesis
BPIBAGO:0007155cell adhesion
BPIEAGO:0007156homophilic cell adhesion via plasma membrane adhesion molecules
BPIBAGO:0007267cell-cell signaling
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007268chemical synaptic transmission
BPIEAGO:0016331morphogenesis of embryonic epithelium

Gene expression in normal tissue: PCDH8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PCDH8


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCDH8

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