GMNN


Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in GMNN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003682 chromatin binding
MF IEA GO:0003714 transcription corepressor activity
MF IPI GO:0005515 protein binding
MF IPI GO:0042826 histone deacetylase binding
MF IEA GO:0070491 repressing transcription factor binding
CC IDA GO:0005634 nucleus
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Gene expression in normal tissue: GMNN

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Metabolic pathways1

Pathways in GMNN


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Database
Pathway ID
Pathway Des.
wikipathways WP466 DNA Replication
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-453279 Mitotic G1-G1/S phases
reactome R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
reactome R-HSA-68867 Assembly of the pre-replicative complex
reactome R-HSA-68874 M/G1 Transition
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GMNN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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