WDPCP
Summary: This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:613580 Ensembl IDEnsembl:ENSG00000143951 HGNC IDHGNC:HGNC:28027 PHARMGKB IDPA164717186 Map Location2p15 | |||||
GO terms in WDPCP
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005930 | axoneme |
| CC | ISS | GO:0005938 | cell cortex |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0097541 | axonemal basal plate |
| BP | IEA | GO:0001822 | kidney development |
Gene expression in normal tissue: WDPCP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WDPCP
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WDPCP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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