RPS27L
Summary: This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S27 like | MIM:612055 | Ensembl:ENSG00000185088 | HGNC:HGNC:18476 | PA38546 | 15q22.2 |
GO terms in RPS27L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003735 | structural constituent of ribosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008494 | translation activator activity |
| MF | IDA | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0022627 | cytosolic small ribosomal subunit |
| BP | IBA | GO:0000028 | ribosomal small subunit assembly |
| BP | IEA | GO:0006412 | translation |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| BP | IMP | GO:0031571 | mitotic G1 DNA damage checkpoint |
| BP | IDA | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IDA | GO:0045727 | positive regulation of translation |
Gene expression in normal tissue: RPS27L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS27L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-192823 | Viral mRNA Translation |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-2408557 | Selenocysteine synthesis |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72764 | Eukaryotic Translation Termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| pid | p53downstreampathway | Direct p53 effectors |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS27L
CLASSFICATION
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