PCNT


Summary: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605925
PHARMGKB IDPA33079
Map Location21q22.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in PCNT


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
BP IMP GO:0000226 microtubule cytoskeleton organization
BP IMP GO:0007052 mitotic spindle organization
BP IEA GO:0007165 signal transduction
BP TAS GO:0010389 regulation of G2/M transition of mitotic cell cycle
BP IDA GO:0060271 cilium assembly
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Gene expression in normal tissue: PCNT

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in PCNT


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-1852241 Organelle biogenesis and maintenance
reactome R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
reactome R-HSA-380259 Loss of Nlp from mitotic centrosomes
reactome R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
reactome R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCNT

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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