PCNT
Summary: The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namepericentrin OMIM IDMIM:605925 Ensembl IDEnsembl:ENSG00000160299 HGNC IDHGNC:HGNC:16068 PHARMGKB IDPA33079 Map Location21q22.3 |
Gene Categories:
TUMOR SUPPRESSORGO terms in PCNT
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
BP | IMP | GO:0007052 | mitotic spindle organization |
BP | IEA | GO:0007165 | signal transduction |
BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
BP | IDA | GO:0060271 | cilium assembly |
Gene expression in normal tissue: PCNT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCNT
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1640170 | Cell Cycle |
reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PCNT
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |