SS18L2

Summary: Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSS18 like 2
OMIM IDMIM:606473
Ensembl IDEnsembl:ENSG00000008324
HGNC IDHGNC:HGNC:15593
PHARMGKB IDPA37990
Map Location3p22.1

GO terms in SS18L2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0003712 transcription coregulator activity
MF IEA GO:0003713 transcription coactivator activity
CC IBA GO:0005634 nucleus
BP IBA GO:0045893 positive regulation of transcription, DNA-templated
BP IBA GO:0045944 positive regulation of transcription by RNA polymerase II
BP IBA GO:0050775 positive regulation of dendrite morphogenesis
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Gene expression in normal tissue: SS18L2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

Pathways in SS18L2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SS18L2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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