RAB9B
Summary: This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAB9B, member RAS oncogene family | MIM:300285 | Ensembl:ENSG00000123570 | HGNC:HGNC:14090 | PA34153 | Xq22.2 |
GO terms in RAB9B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IDA | GO:0019003 | GDP binding |
| MF | IEA | GO:0042802 | identical protein binding |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0012505 | endomembrane system |
| CC | IBA | GO:0030139 | endocytic vesicle |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IEA | GO:0030670 | phagocytic vesicle membrane |
| CC | IDA | GO:0045335 | phagocytic vesicle |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IEA | GO:0015031 | protein transport |
| BP | IBA | GO:0032482 | Rab protein signal transduction |
| BP | IBA | GO:0042147 | retrograde transport, endosome to Golgi |
| BP | TAS | GO:0043312 | neutrophil degranulation |
Gene expression in normal tissue: RAB9B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAB9B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6811440 | Retrograde transport at the Trans-Golgi-Network |
| reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| reactome | R-HSA-8873719 | RAB geranylgeranylation |
| reactome | R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs |
| reactome | R-HSA-9007101 | Rab regulation of trafficking |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAB9B
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.