SEARCH

HOME / SEARCH / MARCH2

MARCH2

Summary: MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemembrane associated ring-CH-type finger 2 OMIM IDMIM:613332 Ensembl IDEnsembl:ENSG00000099785 HGNC IDHGNC:HGNC:28038 PHARMGKB IDPA134993565 Map Location19p13.2

GO terms in MARCH2

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004842	ubiquitin-protein transferase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008270	zinc ion binding
CC	IEA	GO:0005765	lysosomal membrane
CC	IDA	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0005789	endoplasmic reticulum membrane

Showing 1 to 6 of 12 rows rows per page

Gene expression in normal tissue: MARCH2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MARCH2

Loading, please wait...

Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MARCH2

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.