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PHF21A

Summary: The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
PHD finger protein 21A	MIM:608325	Ensembl:ENSG00000135365	HGNC:HGNC:24156	PA134977844	11p11.2

Gene Categories:

HISTONE MODIFICATION

GO terms in PHF21A

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0004407	histone deacetylase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0046872	metal ion binding
CC	IBA	GO:0000118	histone deacetylase complex
CC	IDA	GO:0000118	histone deacetylase complex
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:1990391	DNA repair complex
BP	IBA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0006351	transcription, DNA-templated
BP	TAS	GO:0007596	blood coagulation
BP	IEA	GO:0016575	histone deacetylation

Gene expression in normal tissue: PHF21A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHF21A

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-3214815	HDACs deacetylate histones
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-4839726	Chromatin organization
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHF21A

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DATATYPES

CLASSFICATION

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